Prevention of calcium ionophore-induced release of histamine in rat mast cells by disodium cromoglycate
Johnson, H.G.; Bach, M.K.
Journal of Immunology 114(1 Pt 2): 514-516
1975
ISSN/ISBN: 0022-1767 PMID: 46885 Document Number: 86857
The binding of DSCG to mass cells is transient and may involve complexing of some component (an ion) needed for histamine release. The effect of DSCG to prevent release by the ionophore A-23187 was studied. DSCG, 10-50 .mu.g/ml, prevents both histamine release and 45Ca movement into the rat mast cell induced by the ionophore.
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