Synthesis and interaction studies of oligo and polyamino acids derivatives containing nucleosides
Wada, T.; Mochizuki, E.; Inaki, Y.; Takemoto, K.
Nucleic Acids Symposium Series 25: 19-20
1991
ISSN/ISBN: 0261-3166 PMID: 1842078 Document Number: 369567
Nucleic acid analogs of L-lysine derivatives containing uridine and/or adenosine were synthesized. As dimer models, Lys(Urd)-Lys(Urd) and Lys(Urd)-Lys(Ado) were prepared by activated ester method. These dimers were found to form complex with Poly A, which was observed from hypochromicity of UV spectra. Furthermore poly-L-lysine derivative containing uridine was also prepared. The maximum hypochromicity value of this polymer model with PolyA was higher than that of dimer models.