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Studies on 1,2,3-triazole derivatives as in vitro inhibitors of prostaglandin synthesis

Biagi, G.; Dell'Omodarme, G.; Ferretti, M.; Giorgi, I.; Livi, O.; Scartoni, V.; Tiscione, E.

Farmaco 45(11): 1181-1192

1990

ISSN/ISBN: 0014-827X
PMID: 2128450
Document Number: 350013
This paper reports some new structural modifications (branching and lengthening of alkanoic substituent, increase of heterocycle-carboxylate distance) on 1,2,3-triazole derivative 1, a potent in vitro inhibitor of prostaglandin synthesis, and their influence on enzyme activity. Regarding the structural relationship between 1 and Dazoxiben, a selective thromboxane-synthetase inhibitor, the preparation and activity of some Dazoxiben analogs bearing different heterocycles, are also described.

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