Effects of pyridine and some of its derivatives on prostaglandin synthesis
Sahin, I.; Tuncer, M.; Ayanoğlu, F.G.; Kayaalp, S.O.
Archives Internationales de Pharmacodynamie et de Therapie 270(2): 324-329
1984
ISSN/ISBN: 0003-9780 PMID: 6593009 Document Number: 225610
Effects of pyridine and some of its derivatives namely, nicotinic acid, nicotinyl alcohol, pyridinol carbamate, pyridoxine hydrochloride and pyridostigmine bromide were investigated on the release of a prostaglandin E2-like substance (PGE2-LS) from the isolated perfused rat heart. Furthermore, the effect of neostigmine bromide was also studied as a non-pyridine control compound. At 2 X 10(-5) M concentration, only pyridoxine hydrochloride stimulated the release of PGE2-LS significantly. At 2 X 10(-4) M concentration, pyridine, nicotinic acid and pyridinol carbamate were also found to be active in addition to pyridoxine hydrochloride. At 1 X 10(-3) M concentration, pyridine and all of its derivatives studied increased the release of PGE2-LS significantly. However, neostigmine bromide (1 X 10(-3) M) failed to exert any effect. Indomethacin, a prostaglandin synthetase inhibitor, reduced both the basal release (28%) and the release stimulated by pyridine and its derivatives at 1 X 10(-3) M concentration (more than 50%). These findings suggest that the active substance released is a prostaglandin. It is concluded that the PGE2-LS releasing effect of pyridine and its derivatives from isolated rat heart may be due to the action of the pyridine moiety of the molecules of the compounds studied.