Ganglioside GM3 derivatives and their immunomodulating effect
Diatlovitskaia, E.V.; Koroleva, A.B.; Suskova, V.S.; Emets, V.I.; Sutiusheva, L.V.; Bergel'son, L.D.
Bioorganicheskaia Khimiia 16(3): 402-406
1990
ISSN/ISBN: 0132-3423 PMID: 2141471 Document Number: 364524
The derivatives of ganglioside GM3-NeuLacCer. NeuLacSph and NeuAcLacSphAc-were obtained and their immunomodulating properties studied. These substances are shown to inhibit lymphocyte blast-transformation independently of their ceramide structure. On the contrary, the stimulation by the above GM3-derivatives of Con A-induced T-suppressor activity depends significantly on the structure of their ceramide moiety.