GM3 ganglioside induces hamster fibroblast growth inhibition in chemically-defined medium: ganglioside may regulate growth factor receptor function
Bremer, E.G.; Hakomori, S.
Biochemical and Biophysical Research Communications 106(3): 711-718
1982
ISSN/ISBN: 0006-291X PMID: 6288031 Document Number: 191782
GM3 or GM1 ganglioside exogenously added in chemically-defined medium incorporate equally into cells. However, only GM3 showed a significant growth inhibition to hamster fibroblasts (BHK). The GM3-fed cells became refractory to growth stimulation by fibroblast growth factor (FGF) in chemically-defined media. Radiolabeled Fgf accumulated on GM3-fed cells, but not on GM1-fed cells. Both GM3 and GM1 did not directly interact with FGF. These data suggest that GM3 may regulate the function of the receptors for growth hormones.