Clastogenic effects of copper sulphate on the bone marrow chromosomes of mice in vivo
Agarwal, K.; Sharma, A.; Talukder, G.
Mutation Research 243(1): 1-6
1990
ISSN/ISBN: 0027-5107 PMID: 2300079 Document Number: 355644
Copper sulphate administered intraperitoneally to Swiss albino mice in vivo induced a significant increase in the frequency of chromosomal aberrations in bone marrow cells at all concentrations used (1.1-6.6 mg/kg b.w.), when compared to the negative control. Statistical analysis indicates that the degree of clastogenicity was directly related to the concentrations used and indirectly to the period of exposure. The effect was maximal at 6 h after treatment as compared with 12 and 24 h.