Effects of syngeneic UV-irradiated blood transfusion on the hemopoietic function of the bone marrow in normal state and in craniocerebral injuries in mice
Lobzhanidze, A.A.; Lesnikov, V.A.; Isaeva, E.N.
Biulleten' Eksperimental'noi Biologii i Meditsiny 110(8): 182-185
1990
ISSN/ISBN: 0365-9615 PMID: 2291968 Document Number: 347900
Experiments on mice (CBA X C57 Bl6)F1 using endo- and exogenous cloning have shown that ultraviolet irradiation of blood enhances colony stimulating properties of plasma. Stimulation of colony formation occurs both in vitro, on direct contact of UV-irradiated blood plasma with bone marrow cells, and in vivo, upon this injection to the whole organism. In the latter case, increased migration of colony forming hematopoietic cells from the bone marrow can be noted. Single intravenous injection of syngenic UV-irradiated blood prevents inhibition of hematopoietic function of the bone marrow induced by closed brain injury.