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Interferon-producing activity of bone marrow cells treated with mRNA for interferon when transplanted to irradiated mice

Orlova, T.G.; Zhdanova, L.V.; Mentkevich, L.M.; Shcheglovitova, O.N.; Solov'ev, V.D.

Voprosy Virusologii 5: 541-544

1979

ISSN/ISBN: 0507-4088
PMID: 228497
Document Number: 146432
Inoculation into irradiated (800--850 r) mice of syngeneic bone marrow cells treated with mRNA for interferon (mRNA-If) obtained from chick cells induced with UV-irradiated Newcastle disease virus was accompanied by the appearance in the blood of the animals of a substance with the properties of interferon, inhibiting the cytopathic effect of vesicular stomatitis virus in chick embryo cells but not in mouse L cells. Chicken interferon was detected in the blood of the experimental animals for 7--10 days after transplantation of mRNA-If-treated cells.

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