In vivo effects of indomethacin and cyclophosphamide on CFU-GM proliferation and cyclic nucleotide levels in bone marrow of mice
Fontagne, J.; Bertin, R.; de Marco, F.; Zizine, L.; Adolphe, M.; Portet, R.; Lechat, P.
Biomedicine and PharmacoTherapy 37(9-10): 452-457
1983
ISSN/ISBN: 0753-3322 PMID: 6326884 Document Number: 216761
The effects of indomethacin (6 mg/kg daily, orally, for 4 days) or cyclophosphamide (150 mg/kg, a single dose, intraperitoneally) on myelopoiesis were studied in mice. A hyperplasia of the committed stem cell compartment (rise in the recognizable myeloid precursors, increase of both colony forming capacity and number of CFU-GM in S-phase) associated to an increase of cyclic AMP and GMP amounts in bone marrow cells of treated mice were observed. These results suggest a possible relationship between the in vitro enhancement of proliferative activity of CFU-GM and the in vivo increase of both cyclic nucleotide levels in medullary environment.