Cytogenetic effect of chlordiazepoxide on the bone marrow cells of Swiss mice in vivo
Kar, R.N.; Das, R.K.
Cytobios 36(142): 73-82
1983
ISSN/ISBN: 0011-4529 PMID: 6851658 Document Number: 211922
Chromosomal preparations were examined for structural and numerical abnormalities induced by chlordiazepoxide (CDZ) in mice which received either a single oral dose (20 mg/kg) or multiple doses (10, 20, 40 and 80 mg/kg) for time-response and dose-response studies, respectively. The sampling was done at different post-treatment hours. The structural aberrations recorded were mostly of the chromatid type. CDZ induced a significant increase in chromosomal aberration frequencies at all sampling hours with a peak at 32 h post-treatment. In dose-response studies all the dose groups showed a significant increase over controls but the effect was maximum at the lowest dose level.