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Incorporation of amino acids into liver and serum proteins during prolonged administration to animals of ethanol and cholesterol

Bozhko, G.K.; Chursina, V.S.; Kulabukhov, V.M.

Ukrainskii Biokhimicheskii Zhurnal 62(1): 30-34

1990

ISSN/ISBN: 0201-8470
PMID: 2336722
Document Number: 353720
The synthesis of soluble liver proteins and amino acid incorporation into blood serum proteins were studied in guinea pigs which were daily administered ethanol and cholesterol during 3 months. 9 fractions obtained by electrophoresis in polyacrylamide gel were analyzed. It has been found that ethanol and cholesterol in the liver suppress the synthesis of 4 out of 9 recorded protein fractions. In the serum the ethanol effect against a background of the cholesterol administration is characterized by a sharp decrease of specific radioactivity of albumins while the quantity of the protein fraction is unchanged. These results together with the data available in literature on the ethanol suppression of proteolysis suppose that the joint effect of ethanol and cholesterol is accompanied by a decrease in the blood serum albumin decomposition.

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