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Effect of a single administration of hydrocortisone within various periods of a day on the incorporation of the labeled precursor into nuclear proteins of intact rat liver

Savina, M.I.; Spivak, S.M.

Voprosy Meditsinskoi Khimii 27(3): 352-355

1981

ISSN/ISBN: 0042-8809
PMID: 6792780
Document Number: 178103
A single administration of hydrocortisone within various periods of a day led to distinct and dissimilar alterations in distribution of 14C-lysine in erythrocytes, blood plasma and in liver tissue homogenates. The hydrocortisone injection also changed the synthesis of nuclear proteins, especially during the day time. The ability of cell-targets to accept the hormonal signal depended on the functional state of cell chromatin, which is responsible for realization of the signal effect.

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