Evaluation of hepatoprotective activity of picroliv (from Picrorhiza kurroa) in Mastomys natalensis infected with Plasmodium berghei
Chander, R.; Dwivedi, Y.; Rastogi, R.; Sharma, S.K.; Garg, N.K.; Kapoor, N.K.; Dhawan, B.N.
Indian Journal of Medical Research 92: 34-37
1990
ISSN/ISBN: 0019-5340 PMID: 2189829 Document Number: 351526
Administration of picroliv, a standardized fraction of alcoholic extent of Picrorhiza kurroa (3-12 mg/kg/day for two weeks) simultaneously with P. berghei infection showed significant protection against hepatic damage in Mastomys natalensis. The increased levels of serum glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphate, lipoprotein-X (LP-X) and bilirubin in the infected animals were markedly reduced by different doses of picroliv. In the liver, picroliv decreased the levels of lipid peroxides and hydroperoxides and facilitated the recovery of superoxide dismutase and glycogen. Picroliv had no effect on the degree of parasitaemia.