Oxidative damage of mice erythrocytes infected with Plasmodium berghei
Grieger, M.; Siems, W.; Müller, M.; Grinberg, L.; Leppin, K.
Folia Haematologica 110(4): 581-593
1983
ISSN/ISBN: 0323-4347 PMID: 6196273 Document Number: 216096
By using the model of infection with plasmodium berghei in white mice the attempt was made to explain the oxidative damages of red blood cells as a cause for haemolysis. In addition to a diminished new formation of erythrocytes there was an increased cell lysis under the impact of infection. Without any changes of the Met-Hb-percentage and of Heinz bodies an increase of GSH and GSSG could be measured. The conclusion was drawn that a damage of red blood cells caused by oxidation may occur by changing the relation of reduced tripeptides to oxidised ones.