Immunopathological studies of Plasmodium berghei infected mice: (effect of carbon particles)
Boonpucknavig, S.; Bandaso, R.; Boonpucknavig, V.; Bhamarapravati, N.
Journal of Tropical Medicine and Hygiene 82(4): 79-83
1979
ISSN/ISBN: 0022-5304 PMID: 381681 Document Number: 152219
Swiss albino mice injected intraperitoneally with 105 P. berghei were injected with carbon particles (20 mg the day before and 10 mg on days 4 and 9 after infection) in order to block macrophage activity. Throughout the experiment (15 days), parasitaemia was higher in the carbon-treated mice than in untreated infected mice. Greater amounts of corpuscular malaria antigen, detected in the liver, kidney and spleen from day 3 of infection onwards, were found in the carbon-treated mice. Granular malaria antigen (in the walls of kidney glomerular capillaries, liver Kupffer cells and splenic reticuloendothelial cells), malarial antibody and immune complexes in the kidney were detected in the treated mice.