Protective effect of picroliv, active constituent of Picrorhiza kurrooa, against oxytetracycline induced hepatic damage
Saraswat, B.; Visen, P.K.; Patnaik, G.K.; Dhawan, B.N.
Indian Journal of Experimental Biology 35(12): 1302-1305
1997
ISSN/ISBN: 0019-5189 PMID: 9567764 Document Number: 474040
Picroliv, the active constituent of P. kurrooa, showed a dose dependent (1.5-12 mg/kg, po for 7 days) hepatoprotective activity against oxytetracycline induced hepatic damage in rat. It increased the number of viable hepatocytes (ex-vivo) significantly. Increase in bile volume and its contents in conscious rat suggests potent anticholestatic property. Picroliv also antagonised alterations in enzyme levels (GOT, GPT, and alkaline phosphatase) in isolated hepatocytes and serum, induced by oxytetracycline (200 mg/kg, i.p.) feeding. Picroliv was more potent than silymarin a known hepatoprotective drug.