The protective effect of Ginkgo biloba extract on CCl4-induced hepatic damage
Ozenirler, S.; Dinçer, S.; Akyol, G.; Ozoğul, C.; Oz, E.
Acta Physiologica Hungarica 85(3): 277-285
1997
ISSN/ISBN: 0231-424X PMID: 10101542 Document Number: 472521
The hepatoprotective effects of G. biloba extract (made in Turkey) were studied in rats with CCl4-induced liver damage. Hepatic malondialdehyde, glutathione and hydroxyproline concentrations and histopathologic alterations in liver specimens were assessed. The extract (200 mg/kg, p.o.) was given to rats for 10 days before administration of a single dose of CCl4 (2 ml/kg, i.p.). Pretreatment with the extract reduced hepatic malondialdehyde concentration significantly in CCl4-treated rats, but did not alter glutathione or hydroxyproline concentrations. Light and electron microscopic findings showed that the extract limited CCl4-induced hepatocyte necrosis and atrophy.