New molecular criteria for assessing the toxic action of hydrazine derivatives. Active forms of oxygen as the key agents in the mechanism of toxicity
Avakian, A.K.
Farmakologiia i Toksikologiia 53(1): 70-73
1990
ISSN/ISBN: 0014-8318 PMID: 2158464 Document Number: 347979
The data on metabolism of different derivatives of hydrazine are considered. The generalized conception of the toxic effect of the derivatives is suggested. It is accepted that the toxic effect is connected with an elevation of the level of superoxide radicals occurring during oxidative metabolism of hydrazines.
Document emailed within 1 workday
Related Documents
Gol'dina, O.A.; Tepliakov, V.G.; Demurov, E.A.; Koloskov, I.B.; Zagorevskiĭ, V.A. 1987: Effect of benzamide derivatives on convulsions induced by the toxic action of oxygen in rats Biulleten' Eksperimental'noi Biologii i Meditsiny 104(10): 469-471Urakov, A.L. 1984: Possible mechanism of action of isoquinoline and phenothiazine derivatives, nitrites and nitrates on myocardial oxygen consumption Farmakologiia i Toksikologiia 47(2): 41-43
Filov, V.A.; Stukov, A.N.; Blank, M.A.; Neĭshtadt, E.L. 1978: Experimental data on the toxic action of hydrazine sulfate on the body and on a tumor Farmakologiia i Toksikologiia 41(2): 203-205
Loginov, A.S.; Matiushin, B.N. 1996: Cytotoxic action of active forms of oxygen and mechanisms of development of a chronic process in the liver in liver disease Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 4: 3-5
Ginzburg, S.F.; Ol'shanskaia, N.B.; Ponomarev, G.V.; Stanko, V.I.; Khrapov, V.V. 1975: Effect of aniline and hydrazine derivatives on reversible oxygen addition in model systems of cobalt complexes of etioporphyrin and alpha, beta, gamma, delta-tetraphenylporphine Biofizika 20(6): 987-990
Rahjes, M.E. 1981: Assessing toxic agents: maximizing nurses' proficiency Occupational Health and Safety 50(11): 31-37
Chekunova, M.P.; Frolova, A.D. 1983: Biochemical criteria for assessing cardiotoxic action Gigiena i Sanitariia 5: 11-12
Liu, N.-F.; Qu, L.-B.; Xiang, B.-R.; Yang, R. 2009: Antitumor mechanism of Qinghaosu derivatives--molecular docking studies of Qinghaosu derivatives with transferrin Yao Xue Xue Bao 44(2): 140-144
Matsynin, V.V. 1982: Mechanism of decreased oxygen tension in tissue during hyperoxia and criteria of hyperoxygenation dosage Biulleten' Eksperimental'noi Biologii i Meditsiny 94(11): 9-12
Pokrovskiĭ, A.A.; Tutel'ian, V.A.; Kravchenko, L.V. 1976: Mechanism of the toxic action of the mycotoxin of Fusarium sporotrichiella Voprosy Meditsinskoi Khimii 22(5): 581-596
Vengerovskiĭ, A.I.; Saratikov, A.S. 1988: Mechanism of the action of hepatoprotectors in toxic liver lesions Farmakologiia i Toksikologiia 51(1): 89-93
Kogan, A.K.; Losev, N.I.; Tsypin, A.B.; Manuĭlov, B.M. 1989: The generation of active microbicidal forms of oxygen by leukocytes transiting the vascular bed of the lungs Biulleten' Eksperimental'noi Biologii i Meditsiny 107(6): 688-690
Perkovskaia, G.I.; Kravchuk, Z.N.; Dmitriev, A.P. 2001: Induction of active forms of oxygen by biotic elicitors in tomato cell cultures Ukrains'kyi Biokhimichnyi Zhurnal 73(5): 108-113
Bukharin, O.V.; Sgibnev, A.V.; Cherkasov, S.V. 2008: Active forms of oxygen as a factor regulating surface characteristics of bacterial cells Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 4: 3-6
Skliar, M.I.; Boland, R.L. 1979: Multiple molecular forms of the active principle of Solanum malacox Medicina 39(1): 38-42
Kuchuk, A.A.; Onikienko, F.A.; Blakita, I.V. 1993: The blood serum biochemical indices as criteria for assessing the action on the body of industrial enzyme preparations Likars'ka Sprava 1993(2-3): 102-106
Kravchuk, Z.M.; Perkovs'ka, H.I.; Dmytriiev, O.P. 2003: Role of active forms of oxygen in the induction of phytoalexin synthesis in Allium cepa cells Tsitologiia i Genetika 37(3): 30-35
Lankin, V.Z.; Kogan, A.K.; Kovalevskaia, A.L.; Konovalova, G.G.; Rakita, D.R. 1982: Enzymes of the detoxication of active forms of oxygen and lipoperoxides in experimental ischemia and myocardial infarct Biulleten' Eksperimental'noi Biologii i Meditsiny 93(5): 58-60
Kourounakis, P.N.; Rekka, E. 1994: Effect of spironolactone on dimethyl mercury toxicity. A possible molecular mechanism Arzneimittel-Forschung 44(10): 1150-1153
Serino, F.; Grevel, J.; Napoli, K.L.; Kahan, B.D.; Strobel, H.W. 1994: Oxygen radical formation by the cytochrome P450 system as a cellular mechanism for cyclosporine toxicity Transplantation Proceedings 26(5): 2916-2917