Cytotoxic action of active forms of oxygen and mechanisms of development of a chronic process in the liver in liver disease
Loginov, A.S.; Matiushin, B.N.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 4: 3-5
1996
ISSN/ISBN: 0031-2991 PMID: 9082318 Document Number: 455569
The paper deals with the damaging action of active oxygen forms (AOF) on the cell, which is associated with impairments of membranous structures and their functional properties. Based on the results of their own investigations, the authors forward a concept of the stereotypic pattern of changes in the enzyme mechanisms of AOF utilization in chronic hepatic diseases of viral etiology. It is suggested that impaired hepatocytic AOF formation and inactivation may be metabolic mechanisms mediating the status and development of a chronic process in the liver in its viral damage. Promising approaches to treating oxidative impairments are also discussed.