Vinblastine-C4 alkyl maleoyl and amino acid maleoyl derivatives: I. Chemistry and physicochemical data
Rao, K.S.; Hannart, J.A.; Trouet, A.
Anticancer Research 9(3): 619-624
1989
ISSN/ISBN: 0250-7005 PMID: 2764508 Document Number: 347272
Vinblastine-C4 acyl derivatives were synthesized by linking alkyl maleoyl or amino acid maleoyl compounds through an ester linkage at the C4 position of the vindoline moiety of vinblastine. The condensation of the above mentioned compounds was performed by the mixed anhydride method. Their synthesis, yields and physiochemical data are reported.
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