The fate of the circumsporozoite antigens during the exoerythrocytic stage of Plasmodium berghei
Suhrbier, A.; Hamilton, A.J.; Nicholas, J.; Sinden, R.E.
European Journal of Cell Biology 46(1): 25-30
1988
ISSN/ISBN: 0171-9335 PMID: 3294008 Document Number: 326323
There has been considerable interest in the circumsporozoite proteins due to their potential use in anti-malarial vaccines. Previous authors have shown that these proteins persist from the invading sporozoite throughout the growing exoerythrocytic or liver stage. We show that the different distributions of these proteins seen during the development of the exoerythrocytic parasite of Plasmodium berghei closely follow morphological changes, which can be recognized under the light microscope. At the end of the exoerythrocytic cycle, the majority of the remaining circumsporozoite proteins were associated with the spongy stroma in which the emerging exoerythrocytic merozoites lay. Cell-mediated immunity originally directed against sporozoites might recognize the stroma as a second target resulting in the indirect destruction of the exoerythrocytic merozoites.