Parasite polymorphism present within minimal T cell epitopes of Plasmodium falciparum circumsporozoite protein
Good, M.F.; Pombo, D.; Maloy, W.L.; de la Cruz, V.F.; Miller, L.H.; Berzofsky, J.A.
Journal of Immunology 140(5): 1645-1650
1988
ISSN/ISBN: 0022-1767 PMID: 3279121 Document Number: 324362
Identification of T cell antigenic sites is critical for antisporozoite malarial vaccine design. Here, we present data that define two minimal functional T cell sites present in an immunogenic domain of the circumsporozoite protein of Plasmodium falciparum. These two sites overlap one another and correlate with polymorphic regions of the molecule. This suggests that these polymorphisms may be a result of pressure from immune T cells.
Document emailed within 1 workday
Related Documents
Herrera, S.; Escobar, P.; de Plata, C.; Avila, G.I.; Corradin, G.; Herrera, M.A. 1992: Human recognition of T cell epitopes on the Plasmodium vivax circumsporozoite protein Journal of Immunology 148(12): 3986-3990Russo, D.M.; Sundy, J.S.; Young, J.F.; Maguire, H.C.; Weidanz, W.P. 1989: Cell-mediated immune responses to vaccine peptides derived from the circumsporozoite protein of Plasmodium falciparum Journal of Immunology 143(2): 655-659
Deloron, P.; Campbell, G.H.; Brandling-Bennett, D.; Roberts, J.M.; Schwartz, I.K.; Odera, J.S.; Lal, A.A.; Osanga, C.O.; de la Cruz, V.; McCutchan, T.M. 1989: Antibodies to Plasmodium falciparum ring-infected erythrocyte surface antigen and P. falciparum and P. malariae circumsporozoite proteins: seasonal prevalence in Kenyan villages American Journal of Tropical Medicine and Hygiene 41(4): 395-399
Sharma, A.; Biswas, S. 2005: Stage-specific cytosolic protein kinase C-like activity in human malarial parasite Plasmodium falciparum Indian Journal of Biochemistry and Biophysics 42(3): 145-151
Suwanabun, N.; Sattabongkot, J.; Wirtz, R.A.; Rosenberg, R. 1994: The epidemiology of Plasmodium vivax circumsporozoite protein polymorphs in Thailand American Journal of Tropical Medicine and Hygiene 50(4): 460-464
Charmot, G.; Coulaud, J.P. 1990: Propositions thérapeutiques dans le paludisme A Plasmodium falciparum : le traitement du paludisme : A Plasmodium falciparum en Afrique (à l'exception des formes pernicieuses) - Treatment of malaria at Plasmodium falciparum in Africa (except cerebral malaria) Medecine Tropicale 50(1): 103-108
Akhouri, R.Raj.; Sharma, A.; Malhotra, P.; Sharma, A. 2008: Role of Plasmodium falciparum thrombospondin-related anonymous protein in host-cell interactions Malaria Journal 7: 63
Bottius, E.; BenMohamed, L.; Brahimi, K.; Gras, H.; Lepers, J.P.; Raharimalala, L.; Aikawa, M.; Meis, J.; Slierendregt, B.; Tartar, A.; Thomas, A.; Druilhe, P. 1996: A novel Plasmodium falciparum sporozoite and liver stage antigen (SALSA) defines major B, T helper, and CTL epitopes Journal of Immunology 156(8): 2874-2884
Santiyanont, R.; Wilairat, P. 1983: Identification and localization of antigens of the malaria parasite, Plasmodium falciparum, by immune precipitation Biochemistry International 7(5): 671-676
Ross, A.; Killeen, G.; Smith, T. 2006: Relationships between host infectivity to mosquitoes and asexual parasite density in Plasmodium falciparum American Journal of Tropical Medicine and Hygiene 75(2 Suppl): 32-37
Elm, J.; Desowitz, R.; Diwan, A. 1998: Serological cross-reactivities between the retroviruses HIV and HTLV-1 and the malaria parasite Plasmodium falciparum Papua and new Guinea Medical Journal 41(1): 15-22
Kumkhaek, C.; Phra-ek, K.; Singhasivanon, P.; Looareesuwan, S.; Hirunpetcharat, C.; Brockman, A.; Grüner, A.Charlotte.; Lebrun, N.; Rénia, L.; Nosten, Fçois.; Snounou, G.; Khusmith, S. 2004: A survey of the Th2R and Th3R allelic variants in the circumsporozoite protein gene of P. falciparum parasites from western Thailand Southeast Asian Journal of Tropical Medicine and Public Health 35(2): 281-287
Dejkriengkraikhul, P.; Wilairat, P. 1982: The effect of soluble glycophorin A on invasion of human red cells by the malarial parasite Plasmodium falciparum Southeast Asian Journal of Tropical Medicine and Public Health 13(4): 662-663
Wang, R.; Charoenvit, Y.; Corradin, G.; Porrozzi, R.; Hunter, R.L.; Glenn, G.; Alving, C.R.; Church, P.; Hoffman, S.L. 1995: Induction of protective polyclonal antibodies by immunization with Plasmodium yoelii circumsporozoite protein multiple antigen peptide vaccine Journal of Immunology 155(3): 1637
Brice,B.K.; William,Y.; Lacinan,O.; Leonardo,B.; Joseph,D.A. 2008: Influence of the asexual parasite biomass on in vitro susceptibility of Plasmodium falciparum to antimalarial drugs in Abidjan African Journal Of Biotechnology: 8, 936-940. Ef
Lepers, J.P.; Andriamagatiana-Rason, M.D.; Coulanges, P. 1989: The treatment of Plasmodium falciparum malaria in the Malagasy Highland Plateaux. Development of fever and parasite density. Clinical aspects Archives de l'Institut Pasteur de Madagascar 56(1): 155-159
Rzepczyk, C.M.; Ramasamy, R.; Ho, P.C.; Mutch, D.A.; Anderson, K.L.; Duggleby, R.G.; Doran, T.J.; Murray, B.J.; Irving, D.O.; Woodrow, G.C.; Parkinson, D.; Brabin, B.J.; Alpers, M.P. 1988: Identification of T epitopes within a potential Plasmodium falciparum vaccine antigen. a study of human lymphocyte responses to repeat and nonrepeat regions of Pf155/RESA Journal of Immunology 141(9): 3197-3202
Graves, P.M.; Doubrovsky, A.; Sattabongkot, J.; Battistutta, D. 1992: Human antibody responses to epitopes on the Plasmodium falciparum gametocyte antigen PFS 48/45 and their relationship to infectivity of gametocyte carriers American Journal of Tropical Medicine and Hygiene 46(6): 711-719
Keating, J.; Miller, J.M.; Bennett, A.; Moonga, H.B.; Eisele, T.P. 2009: Plasmodium falciparum parasite infection prevalence from a household survey in Zambia using microscopy and a rapid diagnostic test: implications for monitoring and evaluation Acta Tropica 112(3): 277-282
Udomsangpetch, R.; Troye-Blomberg, M.; Brown, A.E.; Thaithong, S.; Perlmann, P.; Webster, H.K. 1994: Lymphocyte responses to Plasmodium falciparum ring-infected erythrocyte surface antigen (Pf155/RESA) peptides in individuals with naturally acquired Plasmodium falciparum malaria American Journal of Tropical Medicine and Hygiene 50(4): 465-471