Antibodies to Plasmodium falciparum ring-infected erythrocyte surface antigen and P. falciparum and P. malariae circumsporozoite proteins: seasonal prevalence in Kenyan villages
Deloron, P.; Campbell, G.H.; Brandling-Bennett, D.; Roberts, J.M.; Schwartz, I.K.; Odera, J.S.; Lal, A.A.; Osanga, C.O.; de la Cruz, V.; McCutchan, T.M.
American Journal of Tropical Medicine and Hygiene 41(4): 395-399
1989
ISSN/ISBN: 0002-9637 PMID: 2679168 Document Number: 344193
Two cross-sectional surveys of 954 people in Asembo Bay and Got Nyabondo, western Kenya, were performed in August-September 1986, after long rains, and in February-March 1987, after a comparatively dry season. Serological testing was performed using an ELISA with synthetic peptides representing repeat amino acid sequences of the P. falciparum ring-infected erythrocyte surface antigen (RESA), (EENV)5, (EENVEHDA)4, and (DDEHVEEPTVA)2 and repeat sequences (PNAN)5 and (NAAG)5 of the P. falciparum and P. malariae circumsporozoite proteins. In 1986, 45%, 73%, 72%, 85%, and 59% of those in Asembo Bay had antibodies to the respective peptides. In Got Nyabondo, the rates were 44%, 67%, 56%, 36%, and 41%, respectively. All positivity rates increased with age. When next determined in 1987, the positivity rates and levels of reactivity were generally unchanged in Asembo Bay, but were decreased in Got Nyabondo.