Erythrocyte membrane receptor for Plasmodium falciparum

Olson, J.A.

Progress in Clinical and Biological Research 165: 343-359

1984


ISSN/ISBN: 0361-7742
PMID: 6390453
Document Number: 228756
Studies on the chemical nature of molecules on the human erythrocyte surface that mediate infection by P. falciparum are reviewed. The preponderance of evidence indicates that glycophorin A acts as a receptor for P. falciparum. Studies of neuraminidase-treated red cells indicate that the surface charge of the erythrocyte per se is not an important factor in susceptibility to infection. In addition, large proportions of the polypeptide chain of glycophorin A can be removed from the N terminal end by treatment with trypsin without an effect on parasite invasion.

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