Studies on the toxicity, distribution and excretion of emetine
Gimble, A.I.; Davison, C.; Smith, P.K.
Journal of Pharmacology and Experimental Therapeutics 94(4): 431-438
1948
ISSN/ISBN: 0022-3565 PMID: 18122598 Document Number: 3181
The LD50 of emetine in mice was 62 mg./kg. and in rats, 17 mg./kg. The relative concns of emetine in rat and dog tissues were similar and of the following order: liver > kidney >spleen > lung > brain >heart > skeletal muscle> blood. Emetine was stored in the tissues of mice, rats, and dogs and was very slowly destroyed or excreted. It was not excreted in the urine to any appreciable extent.
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