Absorption, distribution, excretion and metabolism of domiodol
Ohtsuki, T.; Takaichi, M.; Jin, Y.; Yokoshima, T.; Kato, R.
Il Farmaco; Edizione Pratica 39(9): 291-309
1984
ISSN/ISBN: 0430-0912 PMID: 6500024 Document Number: 230670
The absorption, tissue distribution, excretion and metabolism of 14C-domiodol were studied after its oral administration to rats. Blood radioactivity was highest 30 min after administration, and declined with a half-life of 2.75 h for the 1st 4 h, and 84.8 h from 48 h to 120 h after administration. Excretion in urine and feces occurred mostly during the 1st 12 h, 47.2% of the administration radioactivity being excreted in urine and 1.3% in feces during 120 h. In expired air, 38.5% of the administered radioactivity was excreted during 120 h. In expired air, 38.5% of the administered radioactivity was excreted during 120 h. In the bile, 38.3% of the administered radioactivity excreted during 48 h. When the bile collected for 6 h was injected intraduodenally into another rat, 35.8% of the injected radioactivity was excreted in the bile and 54.9% in urine. Tissue distribution of radioactivity was high in the liver, kidney, exocrine tissues and bronchi and was low in muscles and white fat. After the oral administration of the labeled drug to male hooded rats, the concentration of radioactivity accumulated in the uvea of the eyeball was similar to that in the blood. Besides the parent compound, 3 metabolites were found in urine and 4 in plasma. In the bile no parent compound was found and one metabolite was recognized.