Streptonivicin, a new antibiotic. V. Absorption, distribution, and excretion
Taylor, R.M.; Miller, W.L.; Vanderbrook, M.J.
Antibiotics and ChemoTherapy 6(2): 162-170
1956
ISSN/ISBN: 0570-3123 PMID: 24543920 Document Number: 15027
Streptonivicin was administered to dogs, mice, and human volunteers in order to ascertain its pattern of absorption, distribution, and excretion. Unusually high and well maintained serum levels were attained, with peak values occurring two to four hours after administration when the antibiotic was given orally to human subjects and dogs in amounts that were anticipated to be in the therapeutic dosage range. In mice, on the other hand, somewhat lower levels were attained, and the peak values occurred within an hour. A. comparison of the serum concentrations attained using various routes of administration in dogs showed that the oral route gave peak values intermediate between the intravenous and intramuscular. Streptonivicin was distributed widely throughout the body tissues and fluid of dogs following oral administration. Somewhat higher concentrations were found in the liver and large intestine than in other tissues. The concentration of streptonivicin in the bile was approximately 16 times that in the serum and urine. Approximately one third of an orally administered dose of streptonivicin was accounted for as biologically active material in the feces of dogs. Only about onehundredth was present in the urine.
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