Top Abstract Purchase Related
Home
>
Node
>
Subnode

Absorption, distribution in tissues and routes of excretion of preparation IF-ROM-196 administered to rats orally

Nowicka, A.; Prussak, T.; Szukalski, B.

Materia Medica Polona. Polish Journal of Medicine and Pharmacy 7(4): 304-307

1975

ISSN/ISBN: 0025-5246
PMID: 1214517
Document Number: 89112
The metabolic fate of a new coronary vasodilating derivative of ethylenediamine (ROM--196) labeled with 14C has been studied in Wistar rats. Dynamics of absorption of the preparation, its distribution in tissues and excretion in urine, feces and bile and expiratory air were investigated. The preparation is quickly absorbed from the gastrointestinal tract and readily penetrates to the tissues. It is excreted mainly in the stools and urine.

Document emailed within 1 workday
Secure & encrypted payments

Gerlóczy, A.; Fónagy, A.; Keresztes, P.; Perlaky, L.; Szejtli, J. 1985: Absorption, distribution, excretion and metabolism of orally administered 14C-beta-cyclodextrin in rat Arzneimittel-Forschung 35(7): 1042-1047
Gladkikh, V.F.; Lebedeva, M.N. 1970: Study of absorption of phenasal administered orally to white rats Meditsinskaia Parazitologiia i Parazitarnye Bolezni 39(1): 88-91
Mascrès, C.; Bonner, M. 1976: Action of acetylsalicylic acid administered by different routes on the blood and buccal tissues of rats Revue Canadienne de Biologie 35(4): 193-197
Nowicka, A.; Prussak, T.; Szukalski, B. 1975: Metabolism of some ethylenediamine derivatives with antiarrhythmic properties. I. Absorption, distribution in tissues and excretion of 14-C labelled N, N'-bis-[3-(p-methoxyphenoxy)-2-hydroxypropyl]-ethylenediamine dimethanesulphonate (MK-142) in rats Polish Journal of Pharmacology and Pharmacy 27(2): 113-120
Fang, F.; Wang, J.-B.; Zhao, Y.-L.; Jin, C.; Kong, W.-J.; Zhao, H.-P.; Wang, H.-J.; Xiao, X.-H. 2011: Tissue distribution of free anthraquinones in SD rats after orally administered extracts from raw and prepared rhubarbs Yao Xue Xue Bao 46(3): 350-354
Shimizu, M. 1970: Experimental study of the distribution of phenylmercuric acetate administered into the vagina and its influence on the embryo. 1. Absorption into the blood and excretion Nihon Sanka Fujinka Gakkai Zasshi 22(4): 350-358
Srivastava, V.M.; Roy, T.K. 1981: Absorption, distribution & excretion of centperazine in male rats Indian Journal of Experimental Biology 19(8): 785-786
Li, D.; Zhu, M.; Yang, X.Y.; Wang, Z.Y.; Li, L.; Yang, S.Y.; Chu, Q.M.; Chen, X.N. 1988: Absorption, distribution and excretion of gallanilide in rats and bioavailability in rabbits Zhongguo Yao Li Xue Bao 9(2): 182-185
Fujii, T.; Matsumoto, S.; Amejima, H.; Hatoyama, T.; Nakao, M.; Kagemoto, A.; Tanaka, K.; Miyazaki, H. 1994: Absorption, distribution, metabolism and excretion of [14C]ebastine after a single administration in rats Arzneimittel-Forschung 44(4): 527-538
Queisnerová, M.; Nĕmecek, O. 1971: Absorption, distribution and excretion rate in diphenyldioxypyrazolidine drugs -14 C-kebuzon and 14 C- trimetazon- in rats Ceskoslovenska Farmacie 20(2): 55-59
Sakai, A.; Iwasaki, M.; Suzuki, T.; Morishita, M.; Muranishi, S. 1988: Studies on the metabolic fate of 14C-rokitamycin. Absorption, distribution, metabolism and excretion in infant rats Japanese Journal of Antibiotics 41(7): 797-808
Kobayashi, S.; Kyui, S.; Yoshida, T.; Nagakura, A.; Oiwa, Y.; Matsumura, R.; Kohei, H. 1981: Absorption, distribution and excretion of 14C-pirenzepine in rats. Accumulation characteristics after multiple dose regimen Arzneimittel-Forschung 31(4): 679-690
Bogomolova, N.S.; Suskova, V.S.; Minakova, S.M.; Chernov, V.A.; Serebriakov, N.G. 1975: Prospidin-C14 blood level, distribution in the organs and tissues and excretion from the body of rats Farmakologiia i Toksikologiia 38(6): 722-728
Suzuki, T.; Serizawa, K.; Somiya, Y.; Shirai, M.; Endo, S.; Morishita, M. 1987: Studies on the metabolic fate of isepamicin sulfate (HAPA-B). I. Absorption, distribution, metabolism and excretion in rats Japanese Journal of Antibiotics 40(1): 188-201
Marzo, A.; Ripamonti, M.; Benatti, P.; Marzo, P.; Wool, C.; Cerutti, R.; Reiner, V. 1997: Absorption and distribution of naproxen in rats orally treated with naproxen betainate sodium salt monohydrate. Comparison with naproxen Arzneimittel-Forschung 47(4): 381-384
Menczel, J.; Rosoff, B.; Spencer, H. 1982: Tissue distribution of orally administered 91Y and 46Sc in mice Health Physics 42(5): 727-730
Uda, F.; Ohashi, H.; Tokiwa, T. 1982: Absorption, distribution, metabolism and excretion of netilmicin in rats (I). Metabolic fate of netilmicin after a single dose Japanese Journal of Antibiotics 35(4): 950-959
Nakamura, A.; Sugihara, K.; Hirota, T.; Morino, A.; Ezumi, Y.; Takaichi, M. 1997: Pharmacokinetics of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate. 1st communication: absorption, distribution and excretion after single administration of 14C-labeled compound to rats and dogs Arzneimittel-Forschung 47(2): 151-159
Katevuo, K. 1979: The effect of intravenously administered glycopyrrolate and orally given analgetic-spasmolytic combination preparation on the contraction of the human gallbladder Annals of Clinical Research 11(2): 83-86
Kresnadi, S.; Harper, M.J.; Lloyd, C.W. 1972: Comparative effectiveness of estrogens as antifertility agents when administered to rats by different routes Endocrinology 90(3): 834-838