Toxicity and Tissue Distribution Studies on the Hydrochloride, Bismuth Iodide Complex and a Resinate of Emetine
Child, K.J.; Davis, B.; Dodds, M.G.; Tomich, E.G.
Journal of Pharmacy and Pharmacology 16: 65-71
1964
ISSN/ISBN: 0022-3573 PMID: 14119543 Document Number: 3197
The HC1, the bismuth-iodide complex and a resinate of emetine were compared on mice, cats and dogs for toxicity, on cats for emetic activity and on rats for distribution of emetine in the tissues. Emetine-hydrochloride, injected subcutaneously, was as toxic as emetine-hydrochloride or emetine-bismuth-iodide administered orally, but only 1/6 as emetic. Given orally emetine-resinate was considerably less toxic and emetic than the other preparations. The patterns of emetine distribution in the tissues of rats were similar for all the preparations, but the tissue concentrations were much lower with emetine-resinate. In infected rats the resinate was as amoebicidal as the HCl or the bismuth-iodide complex. Emetine-resinate might be better than emetine-iodide for the treatment of intestinal amoebiasis.
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