Selective damage of myocardial mitochondria due to emetine hydrochloride
Pearce, M.B.; Bulloch, R.T.; Murphy, M.L.
Archives of Pathology 91(1): 8-18
1971
ISSN/ISBN: 0363-0153 PMID: 5538625 Document Number: 5734
Emetine hydrochloride was given by injection to 26 mongrel dogs, and its cardiac effects were studied by serial hemodynamic measurements, electrocardiograms, and myocardial biopsies. The serial biopsy method used in this report emphasizes a different approach to the study of experimental myocardial damage. Serial ECGs of 16 dogs revealed development of marked T wave change in three, right bundle branch block in ten (due to repeated septa) biopsies), and normal ECGs in three. Right and left heart pressure were normal in those animals studied. Light microscopy was normal in all animals. Selective myocardial damage limited to the mitochondria was noted by electron microscopic examination of biopsies from 14 dogs. Mitochondrial damage was characterized by partial to complete loss of mitochondrial cristae. Repeated biopsies of one animal indicated that mitochondrial change produced by emetine can be reversible.
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