Distribution and excretion of 3H-sterigmatocystin in rats
Wang, D.S.; Sun, H.L.; Xiao, F.Y.; Ji, X.H.; Liang, Y.X.; Han, F.G.
Iarc Scientific Publications 105: 424-426
1991
ISSN/ISBN: 0300-5038 PMID: 1855893 Document Number: 373317
In order to investigate the distribution and excretion of sterigmatocystin, a carcinogenic mycotoxin, radioactively labelled compound was studied in rats. The highest concentration of radioactivity in serum appeared 3 h after administration of 0.5 microCi/g bw. The half-lives of distribution and excretion were 0.51 h and 43.9 h, respectively. The radioactivity was concentrated mainly in liver, stomach, kidney, duodenum and lung and to a lesser extent in fat, muscle, testis, rectum and bone. By 48 h, 56.4% had been excreted in faeces and 20.1% in urine. Biliary excretion may be the major route of excretion of sterigmatocystin.