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QSAR studies of hydrazone uncouplers of oxidative phosphorylation

Winkler, D.A.; Holan, G.; Smith, D.R.; Middleton, E.J.; Hart, N.K.; Rihs, K.; Smith, K.W.

Drug Design and Delivery 3(2): 191-207

1988

ISSN/ISBN: 0884-2884
PMID: 3255329
Document Number: 316629
Semiempirical molecular orbital calculations have been performed on a series of hydrazone uncouplers of mitochondrial oxidative phosphorylation which show insecticidal activity. Regression analysis yielded significant correlations between uncoupling activity, insecticidal potency and such physicochemical or theoretically-derived parameters as lipophilicity, pKa and atom charges.

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