Tissue-specific uncouplers of oxidative phosphorylation in mitochondria from rat heart, kidney, thymus and lung
Elbakidze, G.M.
Biulleten' Eksperimental'noi Biologii i Meditsiny 87(2): 149-151
1979
ISSN/ISBN: 0365-9615 PMID: 420934 Document Number: 147187
The influence of nonmicrosomal cytoplasm fraction from the rat kidney, heart, thymus and lungs on the oxidative phosphorylation of mitochondria (M) of the same tissues and from the ones of the liver and brain was studied. The existence of the tissue-specific uncouplers of the M oxidative phosphorylation was shown in the cross experiments; they were similar to that in the rat liver revealed earlier. A possibility of these regulators participation in the initiation of the M enzymatic degradation process through the activation of phospholipase A when calcium ions leave the M is discussed. The activation under these conditions of the DNA-ase 1, associated with the M membrane, is suggested.