Acetylcholine and effectiveness of oxidative phosphorylation in isolated rat hepatocytes

Gordiĭ, S.K.; Shostakovs'ka, I.V.; Doliba, M.M.

Ukrainskii Biokhimicheskii Zhurnal 65(5): 98-102

1993


ISSN/ISBN: 0201-8470
PMID: 8160306
Document Number: 413963
It is shown that ADP and DNP does not intensify the respiration rate in hepatocytes of rats obtained by means of trypsin or EDTA. The same cells obtained using collagenase, phosphorylate added ADP and increase the respiration rate after DNP addition. Acetylcholine added to the cell suspension in a dose of 5 x 4 x 10(-8) M) increases the efficiency of oxidative phosphorylation. The scheme of neurotransmitter regulation of intensity of respiration and efficiency of oxidative phosphorylation on the cell level is suggested.

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