The role of long-chain acyl-CoA in the disturbances of oxidative phosphorylation in the myocardium
Borutaĭte, V.I.; Mildazhene, V.I.; Ivanovene, L.I.; Kholodenko, B.N.; Toleĭkis, A.I.; Prashkiavichius, A.K.
Biokhimiia 54(12): 1947-1951
1989
ISSN/ISBN: 0320-9725 PMID: 2633800 Document Number: 337994
The effect of intramitochondrial acyl-CoA on the respiration of rabbit heart mitochondria in different metabolic states was studied. Acyl-CoA inhibited O2 consumption by 11% in State 4 and by 6% in State 3. However, the effect of acyl-CoA was more pronounced (20%) in the intermediate state of respiration between State 4 and State 3. The data obtained suggest that acyl-CoA can regulate oxidative phosphorylation in heart mitochondria in vivo.