Synthesis and antibacterial activity of new cephalosporines containing a pyrrole ring in the N-acyl chain
Bijev, A.; Radev, I.; Borisova, Y.
Die Pharmazie 55(8): 568-571
2000
ISSN/ISBN: 0031-7144 PMID: 10989832 Document Number: 1967
Nine new cephalosporines containing a pyrrole ring in the N-acyl chain have been synthesized by the N-acylation of 7-ACA or of its 3-analogues via the acid chlorides of substituted 2-pyrrole-carboxylic, -acetic or -propionic acids. H1 NMR and IR data confirming the structure are presented. Preliminary microbiological tests in vitro show significant antibacterial activity, compared with that of cefalexin. Some common structure-activity relationships have been observed.
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