Changes in oxidative phosphorylation following exposure to sodium caffeine benzoate
Urakov, A.L.
Voprosy Meditsinskoi Khimii 26(2): 198-200
1980
ISSN/ISBN: 0042-8809 PMID: 7456349 Document Number: 165280
Sodium caffeine-benzoate at concentrations 6 x 10(-6) M and 6 x 10(-5) M increased the rate of free oxidation of succinic acid in myocardial mitochondria suggesting possibility of uncoupling of respiration and oxidative phosphorylation. The drug stimulates the free flow of electrons in respiratory chain. These phenomena might be responsible for an increase in metabolism and body temperature in patients after the treatment with this drug.