QSAR studies on psychotomimetic phenylalkylamines
Gupta, S.P.; Handa, A.; Bindal, M.C.; Singh, P.
Arzneimittel-Forschung 33(8): 1089-1090
1983
ISSN/ISBN: 0004-4172 PMID: 6685483 Document Number: 5683
Attempts have been made to correlate hyperthermic potencies in rabbits and LSD-like effect in rat of a series of phenylisopropylamines (amphetamines) with physico-chemical parameters. In case of 2,4,5-trisubstituted analogs, hyperthermic potencies are found to be well correlated parabolically with the hydrophobic parameter pi. However, for the same series, the LSD-like effect is found to be related with pi in combination of steric parameter of 4-substituent. It is therefore inferred that hyperthermia in rabbit may be the function only of the hydrophobic character of molecule, but the LSD-like effect is influenced by the steric hindrance of 4-substituent also.
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