Observations of plasma and urinary steroid levels following the administration of zinc-ACTH and gel-ACTH
Siegel, S.C.; Lovin, B.J.; Smith, R.; Ely, R.S.; Kelley, V.C.
Annals of Allergy 16(3): 252-267
1958
ISSN/ISBN: 0003-4738 PMID: 13545699 Document Number: 3155
Zinc-ACTH and gel-ACTH were administered intramuscularly in normal subjects to determine their potency and duration of activity. The method employed consisted of directly measuring the circulating plasma 17-OHCS (hydroxycorticosteroid) levels, the total 24-hour urinary excretion concentrations of 17-OHCS and 17 ketosteroids, and determining the eosinopenic response following the administration of these preparations. The results of these studies indicate that zinc-ACTH is longer acting than gel-ACTH. The duration of activity of zinc-ACTH, as determined by the plasma 17-OHCS response, persists from 8 to 16 hours, but is less than 24 hours. That the duration of activity of zinc-ACTH is not more than 24 hours was further suggested by the return to normal after 24 hours of the urinary 17-KS and 17-OHCS excretion values.
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