Effects of flunitrazepam-pentazocine-N2O anesthesia and surgery on plasma catecholamines, ACTH, cortisol and ADH levels in man
Takiguchi, M.; Yodono, M.; Miyahara, T.; Ogino, R.; Kudo, M.; Kudo, T.; Oyama, T.
Masui. Japanese Journal of Anesthesiology 30(6): 559-565
1981
ISSN/ISBN: 0021-4892 PMID: 6279901 Document Number: 172821
The effects of modified neuroleptanesthesia consisting of flunitrazepam or diazepam combined with pentazocine-N2O, and surgery on the endocrine function in man were investigated. Fourteen patients who underwent gynecolgical operations were divided into 2 groups. Seven patients were anesthetized with modified NLA with flunitrazepam and pentazocine-N2O, and another group of 7 patients was anesthetized with diazepam, pentazocine-N2O. Plasma catecholamines, epinephrine and norepinephrine, ACTH, cortisol and ADH levels were determined on 5 occasions: preinduction which served as control, 30 min after the start of anesthesia, 30 and 60 min after the start of the operation, and in the recovery room. In the flunitrazepam group, plasma catecholamines, ACTH and cortisol levels increased slightly and plasma ADH levels increased markedly during anesthesia alone. All parameters elevated significantly peri- and postoperatively. In the diazepam group, plasma catecholamines, ACTH, cortisol and ADH levels changed markedly during anesthesia alone but they increased significantly during and after surgery. No significant increase in plasma ADH levels was detected. No significant difference was found at any time in plasma catecholamines, ACTH, cortisol and ADH levels between the flunitrazepam and diazepam groups. Modified NLA anesthesia with flunitrazepam and pentazocine-N2O may stimulate the endocrine function slightly as much as NLA consisting of diazepam and pentazocine-N2O does.