Observations on some hematological effects of cobalt-iron mixtures
Rohn, R.J.; Bond, W.H.
Journal-Lancet 73(8): 317-324
1953
ISSN/ISBN: 0096-0233 PMID: 13096934 Document Number: 3156
A cobalt-iron preparation containing 70 mg. of ferrous sulfate and 40 mg. of cobalt chloride for each 0.6 cc. of aqueous solution was used in the treatment of 23 infants with uncomplicated nutritional iron deficiency anemias. In two adults and one infant with moderately severe to severe pan-marrow hypoplasia, cobalt chloride alone was administered in 120 to 200 mg. dosage per day. The preparations were acceptable and tolerated without appreciable toxic reactions. Cobalt caused markedly increased levels of circulating ervthrocytes, leukocytes, and thrombocytes in the majority of the patients, and in some there was noted a significant elevation of circulating eosinophilic and basophilic leukocytes. Some possible mechanisms by which these elevated levels could be obtained with cobalt were discussed. Possible indications for cobalt and cobalt-iron preparations were also suggested.
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