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The synthesis and antineoplastic activity of substituted benzaldehyde arylsulfonylhydrazones

He, X.F.; Tang, L.; He, L.; Xu, P.L.

Hua Xi Yi Ke da Xue Xue Bao 19(3): 317-319

1988

ISSN/ISBN: 0257-7712
PMID: 3253182
Document Number: 307586
Fifteen derivatives of substituted benzaldehyde arylsulfonyl-hydrazones were synthesized and evaluated in vitro against human stomach cancer cells SGC 7901 and mice bone marrow cancer cells SP 2/0. The compound (10) killed about 2/3 of SGC 7901 cells compared with the control group in the culture of 100 .mu.g/ml concentration. Compounds (2), (3), (9), and (10) killed all of the SP 2/0 cancer cells in the culture of 50 .mu.g/ml concentration. With the exception of p-nitrobenzaldehyde benzulfonylhydrazone, the remaining 14 are new compounds, whose structures were confirmed by elementary analyses, IR and 1HNMR spectra.

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