Effect of dihydropyridines on cation transport across the skeletal muscle membrane in the frog
Shvinka, N.E.; Caffier, G.; Vinogradova, T.A.; Velena, A.K.; Bisenieks, E.A.
Tsitologiia 30(10): 1254-1260
1988
ISSN/ISBN: 0041-3771 PMID: 2854317 Document Number: 307585
2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(o-difluromethoxyphenyl)- 1,4-dihydropyridine (ryodipine) blocks Ca-channels in phasic muscle fibres from ileofibularis and semitendinosus muscle of Rana esculenta. Ryodipine and some other newly synthesized dihydropyridines (10(-7)-10(-4) M) exerted a slight, if any, effect on the steady-state of potassium chord conductance in isotonic K+-sulfate solution. The effluxes of potassium and rubidium from the sartorius muscle of Rana temporaria also remained unchanged after addition of 2 x 10(-4) M ryodipine. Thus, the nonspecific dihydropyridine effect on ion transport seems to be poorly expressed.