Top Abstract Purchase Related
Home
>
Node
>
Subnode

Antiviral activity of naphthoquinones. I. Lapachol derivatives against enteroviruses

Pinto, A.V.; Pinto, M.de.C.; Lagrota, M.H.; Wigg, M.D.; Aguiar, A.N.

Revista Latinoamericana de Microbiologia 29(1): 15-20

1987

ISSN/ISBN: 0187-4640
PMID: 2820010
Document Number: 296658
Some derivatives obtained by chemical transformation of lapachol (a natural substance extracted from the core of plants belonging to the family Bignoniaceae) were studied as to their possible antiviral action. Cell cultures were treatd with those substances and then inoculated with poliovirus type 1, echovirus 19 and Coxsackievirus B type 4. Only .beta.-lapachone, succinamidyl-.beta.-norlapachone and intermediary of Hooker have shown a significant viral inhibition index to echovirus type 19. Those derivatives had in in vitro antiviral action but they did not cause any harm to the viral particles studied (virucidal action).

Document emailed within 1 workday
Secure & encrypted payments

Achilova, G.S.; Auelbekov, S.A.; Aslanov, K.A.; Barinskiĭ, I.F. 1989: Antiviral activity of derivatives of aldehydophenols, aldehydo- naphthols and sugar derivatives Voprosy Virusologii 34(3): 315-319
Shetgiri, N.P.; Kokitkar, S.V.; Sawant, S.N. 2001: Radermachera xylocarpa: the highly efficient source of lapachol and synthesis of its derivatives Acta Poloniae Pharmaceutica 58(2): 133-135
Martani, A.; Fravolini, A.; Schiaffella, F.; Orzalesi, G.; Selleri, R.; Volpato, I. 1975: Pyridine derivatives with potential antiviral activity Bollettino Chimico Farmaceutico 114(10): 590-597
Lozyuk, L.V.; Potopal'skii, A.I. 1978: Antiviral activity of the thiophosphamide derivatives of the alkaloids of celandine Mikrobiolohichnyi Zhurnal 40(1): 92-97
Il'icheva, T.N.; Kulishova, L.A.; Shul'ts, E.E.; Petrenko, N.I.; Uzenkova, N.V.; Ias'ko, M.V.; Serova, O.A.; Volkov, G.N.; Belanov, E.F.; Tolstikov, G.A.; Pokrovskiĭ, A.G. 2005: Antiviral activity of vegetable triterpens, their derivatives and ribavirin phosphonates Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 2005(2): 26-30
Nosik, N.N.; Nebol'sin, V.E.; Zheltukhina, G.A.; Evstigneeva, R.P.; Kondrashina, N.G.; Lavrukhina, L.A.; Krzhechkovskaia, V.V. 2003: Antiviral and anti-stress activity of the gamma-L-glutamyl-histamine and its derivatives Voprosy Virusologii 48(1): 38-42
Shchaveleva, I.L.; Kochetkova, S.V.; Tsilevich, T.L.; Vladyko, G.V.; Korobchenko, L.V.; Boreko, E.I.; Smirnov, I.P.; Khorlin, A.A.; Gottikh, B.P.; Florent'ev, V.L. 1989: Compounds, similar to acyclovir V. Synthesis and antiviral activity of carbethoxyalkoxymethyl derivatives of nucleic bases Bioorganicheskaia Khimiia 15(7): 960-968
Lyakhov, S.A.; Suveyzdis, Y.I.; Litvinova, L.A.; Andronati, S.A.; Rybalko, S.L.; Dyadyun, S.T. 2000: Biological active acridine derivatives. Part 4: Synthesis and antiviral activity of some bis-acridinylated diamides Die Pharmazie 55(10): 733-736
Balzarini, J.; Pelemans, H.; Aquaro, S.; Perno, C.F.; Witvrouw, M.; Schols, D.; De Clercq, E.; Karlsson, A. 1996: Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication Molecular Pharmacology 50(2): 394-401
Sokolov, I.N.; Chekhova, A.E.; Eliseev, I.T.; Nilov, G.I.; Shcherbanovskiĭ, L.R. 1972: Antimicrobial activity of naphthoquinones Prikladnaia Biokhimiia i Mikrobiologiia 8(2): 261-263
Sorodoc, Y.; Danielescu, G.; Burducea, O.; Cajal, N.; Niclescu-Duvăz, I.; Baracu, I. 1977: Investigations of the antiviral activity of some nitroso-urea derivatives. Inhibitory action of the IOB-252 nitroso-urea derivative on vaccinia virus incell cultures Virologie 28(1): 55-61
Roushdi, I.M.; Ibrahim, E.S.; Habib, N.S. 1976: Synthesis of 1.4-naphthoquinones-4-aryl(aroyl)hydrazones of potential antimicrobial activity Die Pharmazie 31(12): 856-859
Cabrerizo, M.; Grupo Para El Estudio de Las Infecciones Por Enterovirus Y Parechovirus, G.P.E.E.d.L.I.P.E.Y.P. 2017: Importance of enteroviruses in neuropaediatrics: from polioviruses to other enteroviruses Revista de Neurologia 64(S03): S35-S38
Nardi, D.; Massarani, E.; Rossi, S.; Degen, L.; Altucci, P.; Catalano, G.; Varone, G.L. 1974: Antiviral compounds. XVI. p-Alkylthiophenylglyoxals and their derivatives Il Farmaco; Edizione Scientifica 29(6): 473-481
Kojima, E.; Ohta, K.; Miyawaki, S.; Date, T.; Machida, M.; Murakami, K. 1995: Synthesis and antiviral activities of 9-cyclopentylpurine derivatives Nucleic Acids Symposium Series 34: 107-108
Alunni Bistocchi, G.; De Meo, G.; Pedini, M.; Ricci, A.; Bastianini, L.; Sposini, T.; Sbaraglia, G.; Jacquignon, P. 1986: New heterocyclic derivatives of benzimidazole with germicidal activity. III. Synthesis and activity of derivatives of (formyl-5'-furyl-2')-2-benzimidazole with different substitutions at position 5 Il Farmaco; Edizione Scientifica 41(12): 970-983
Tonew, E.; Löber, G. 1978: Antiviral pyrimidine derivatives: binding with biopolymers and photosensitization Acta Virologica 22(1): 45-51
Balkan, A.; Akgün, H.; Parali, N.; Ertan, M.; Açikgöz, C.; Ustaçelebi, S. 1996: New naphthyloxyalkyl beta-diketone and 3,5-dimethylisoxazole derivatives as potential antiviral agents Farmaco 51(8-9): 589-594
Sidzhakova, D.; Mardirossjan, Z.; Galabov, A.; Tabakova, S.; Golovinsky, E. 1995: Synthesis and study of derivatives of cyclic carbamides with antiviral and antimicrobial action Folia Medica 37(4a Suppl): 28
Rádl, S.; Zikán, V.; Smejkal, F. 1985: Preparation of 4-phenoxy and 4-phenylthio derivatives of 1H-pyrazolo[3,4-b]-quinoline with an antiviral effect Ceskoslovenska Farmacie 34(3-4): 119-122