Antiviral activity of vegetable triterpens, their derivatives and ribavirin phosphonates
Il'icheva, T.N.; Kulishova, L.A.; Shul'ts, E.E.; Petrenko, N.I.; Uzenkova, N.V.; Ias'ko, M.V.; Serova, O.A.; Volkov, G.N.; Belanov, E.F.; Tolstikov, G.A.; Pokrovskiĭ, A.G.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 2005(2): 26-30
2005
ISSN/ISBN: 0869-6047 PMID: 15776963 Document Number: 584711
The purpose of the study was to investigate, in the Vero cell culture, the antiviral activity of vegetable tritrpens derivatives and ribavirin analogues against the viruses of measles, herpes simple (type 1), cytomegaloviruses and filoviruses. The toxicity and antiviral activity of compounds were determined after coloring of cells with crystal violate. Additionally, the combined action of triterpens' derivatives and ribavirin was investigated. The studied compounds showed relatively low antiviral activity, nonetheless, further research of vegetable triterpens and their derivatives as well as ribavirin analogues would be promising.