Study of anti-HIV activity of azidothymidine and fluorothymidine 5'-phosphonates
Mamaeva, O.A.; Pliasunova, O.A.; Pokrovskiĭ, A.G.; Diatkina, N.B.; Arzumanova, A.A.
Molekuliarnaia Biologiia 28(1): 137-142
1994
ISSN/ISBN: 0026-8984 PMID: 8145741 Document Number: 423255
It was established that 5'-phosphonates of 3'-azido-2',3'-dideoxythymidine (AZT) inhibit HIV reproduction in the MT-4 cell line as well as AZT. However, the viability of HIV-infected MT-4 cells after treatment with phosphonates was considerable higher that after AZT treatment. Inhibitory activities of 5'-phosphonates of 3'-fluoro-2',3'-dideoxythymidine (FLT) on HIV-infected MT-4 cells were rather low. The mechanism of action of these derivatives and prospects for their application for suppressing HIV infection are discussed.