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Ultrastructural study of azidothymidine-induced melanoderma in an AIDS patient

Hermanns-Lê, T.; Gérardy-Goffin, F.; Giet-Lesuisse, M.; Piérard, G.E.

Annales de Pathologie 13(5): 328-331

1993

ISSN/ISBN: 0242-6498
PMID: 8311859
Document Number: 421313
We report an ultrastructural study of azidothymidine-induced melanoderma. The hyperpigmentation is linked to the presence of numerous single melanosomes and polymelanosomes in keratinocytes at all levels of the epidermis, and in dermal Factor XIIIa-positive dendrocytes. Such observation suggests an increased melanogenesis in melanocytes associated to a defect in the degradation of melanosomes normally occurring during epidermal maturation.

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