Advances in the study of the anti-tumor activity of small molecule vascular disrupting agents
Cai, Y.-c.; Zou, Y.; Xian, L.-j.
Yao Xue Xue Bao 45(3): 283-288
2010
ISSN/ISBN: 0513-4870 PMID: 21351502 Document Number: 642512
Vascular disrupting agents (VDAs) have presented a new kind of anti-cancer drug in recent years. VDAs take advantage of the weakness of established tumor endothelial cells and their supporting structures. In contrast to anti-angiogenic therapy, which inhibits the outgrowth of new blood vessels, vascular targeting treatments selectively attack the existing tumor vasculature. Here we summarized the anti-tumor activities, mechanisms and clinical applications of small molecule VDAs.
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