Pharmacokinetics of clozapine in rabbits
Zeng, Y.L.; Wang, Z.R.; Lu, M.L.
Yao Xue Xue Bao 21(8): 566-571
1986
ISSN/ISBN: 0513-4870 PMID: 3811949 Document Number: 272997
A pharmacokinetic study on Clozapine was carried out on 6 rabbits. Serum specimens were assayed by a RPHPLC method. Using PCNONLIN program, the C vs t data were fitted to the linear mammillary models by nonlinear least-squares method. The discrimination among one, two and three-compartment models were mainly based upon AIC values. A better computer fit to a three compartment model was observed. The primary and secondary parameters obtained were presented in tab 3 and tab 4, respectively. The above-mentioned parameters were discussed in comparison with the results obtained by statistical moment analysis.